Modeling and Control of the Crystallization Kinetics of Organic Electrolytes

拟议的研究涉及制定原则， 有机电解质结晶产物工程 解决方案 模型充分描述成核和 生长速率，并阐明沉淀机制 有机电解质已经被提议用于实验 验证 重点将放在发展 用于预测添加剂的包含的化学方法 沉淀物和所包含的添加剂对 沉淀物晶体的性质。 这项研究的意义在于它与 固体设计具有精心设计的物理化学和 生物学特性 这些特性可以显著地 影响药品的生物活性。 它 预计该项目的目标将得以实现 通过研究一元酸的沉淀动力学， （二苯基乙内酰脲）和氨基酸（谷氨酸）。 的 其他氨基酸和其他结构相关的影响 添加剂将从结构和动力学两个方面进行研究 观点。

The proposed research relates to development of principles for engineering the crystallization product of organic electrolyte solutions. Models to describe adequately the nucleation and growth rates and to elucidate precipitation mechanisms of organic electrolytes have been proposed for experimental verification. Emphasis will be placed on developing heuristics for predicting the inclusion of the additives in the precipitate and the role of included additives on the properties of the precipitate crystals. The significance of this research is its relation to the design of solids with carefully engineered physicochemical and biological properties. These properties can dramatically affect the biological activity of pharmaceutical products. It is expected that the goals of the project will be accomplished by studying the precipitation kinetics of a monoprotic acid (diphenylhydantoin) and an amino acid (glutamic acid). The influence of other amino acids and other structurally related additives will be studied from both a structural and a kinetic points of view.