Theoretical Study of Boron Anionic Heterocycles Derived fromHydroxamic Acids

该奖项支持纽约市立大学亨特学院的约瑟夫·丹嫩伯格和乌拉圭蒙得维的亚共和国大学的奥斯卡·文图拉的合作研究。他们将研究从羟基肟酸衍生的硼阴离子杂环的理论。分子轨道计算将用于模拟取代羟基肟酸的互变异构（结构异构体的相互转化）。这些酸是脲酶的抑制剂但在硼酸存在的情况下不起作用所以硼酸和羟肟酸之间的反应将被研究。这是化学家们非常感兴趣的一个项目，两位合作者都很有资格，也很有成效。两国都有有效的国际合作历史。丹嫩伯格的实验技巧与乌拉圭人的理论技巧相辅相成。因此，该项目代表了美国和拉丁美洲科学家在前沿化学领域的合作，也是实现发展中国家科学计划目标的一个很好的例子。

This award supports cooperative research between Joseph Dannenberg of Hunter College at the City University of New York (CUNY) and Oscar Ventura of the University of the Republic in Montevideo, Uruguay. They will study the theory of boron anionic heterocycles derived from hydroxamic acids. Molecular orbital calculations will be used to model the tautomerism (interconversion of structural isomers) of substituted hydroxamic acids. These acids are inhibitors of urease but not in the presence of boric acid so the reaction between this acid and hydroxamic acid will be studied. This is a project of fundamental interest to chemists and the two collaborators are well qualified and productive. Both have a history of effective international collaboration. Dannenberg's experimental skills complement the theoretical ones of the Uruguayan. Therefore this project represents a cooperation in frontier chemistry between U.S. and Latin American scientists and a good example of fulfillment of the goals of the Science in Developing Countries program.