U.S.-Brazil Cooperative Research on Seven-Membered Rings ViaNitrenium Ions

该奖项支持合作研究， 碳键七元环形成化学 由克莱姆森的鲁道夫·阿布拉莫维奇执行 大学和J.A.R.罗德里格斯大学 巴西的坎皮纳斯。 一种新的形成方法， 七元环，以前发现的 合作者，将扩大到生产 同环和杂环，以确定 有利于环的结构和几何因素 阵 然后，分子的便捷途径 与天然存在的抗癌剂相关的药物将 接受检查。 这将导致编写一份 保留有用的生物活性的各种衍生物 活性，但毒性降低。 目标是 开发温和的，有用的途径， 生物活性化合物。 这项工作是一项富有成效的 在坎皮纳斯，一个前 其成员目前正在圣保罗建立一个 研究生课程与18名研究生，和 克莱姆森的阿布拉莫维奇医生的小组。 巴西 P.I.和一个学生都在克莱姆森待过 这有助于建立一个小的 坎皮纳斯的研究小组正在研究 芳基氮鎓离子化学 这项研究将增加 关于形成、结构和 芳基氮鎓和芳基氧鎓离子与键的反应性 在广泛存在的七元环中形成 在自然界中， 和药物治疗。

This award supports cooperative research in the chemistry of carbon-bond seven-membered ring formation to be carried out by Rudolph Abramovitch of Clemson University and J.A.R. Rodriguez of the University of Campinas in Brazil. A new method of formation of seven-membered rings, previously discovered by the collaborators, will be extended to the production of homo- and hetero-cyclic rings to determine the structural and geometrical factors which favor ring formation. Then, convenient routes to molecules related to naturally-occurring anticancer agents will be examined. This will lead to the preparation of a variety of derivatives which retain useful biological activity but with reduced toxicity. The objective is to develop mild, useful routes to desirable biologically active compounds. This work is a continuation of a productive cooperation between the group at Campinas, a former member of which is now at Sao Paulo establishing a graduate program with eighteen research students, and Dr. Abramovitch's group at Clemson. The Brazilian P.I. and a student have both spent time at Clemson which has helped in the establishment of a small research group at Campinas now working on arylnitrenium ion chemistry. This study will increase the knowledge of the formation, structure and reactivity of arylnitrenium and -oxenium ions and bond formation in seven-membered rings which occur widely in nature and have been the target of much scientific and medicinal attention.