Rhodium-Catalyzed Hydroboration Reactions in Organic Synthesis

凯文·伯吉斯的工作得到了合成有机的支持。 化学课程。 伯吉斯，助理教授， 莱斯大学的化学教授，正在研究 通过铑催化剂的硼氢化反应。 的 非催化硼氢化反应对 有机合成;催化过程将使下一个 这是化学物质效用的重大改进。 伯吉斯 将利用手性铑络合物将手性引入 硼氢化过程。 机械研究，以及 范围和限制的一般性审查 开发技术，将是这一新的重点 程序. 该提案概述了开发铑催化的 用于制备有机化合物的常规硼氢化反应 化学. 不同结构的不对称硼氢化反应 纯手性铑-膦络合物将被检查， 包括未官能化和官能化的基底 前手性烯烃和一系列手性烯丙基/高烯丙基 化合物. 同时进行的机制研究 这些通用的合成探针将被用来确定 更好地理解所涉及的基本化学， 找到改变和改进技术的方法。

The work of Kevin Burgess is supported by the Synthetic Organic Chemistry Program. Burgess, an assistant professor of chemistry at Rice University, is studying the catalysis of hydroboration reactions by rhodium catalysts. The non-catalyzed hydroboration reaction has had a major impact on oprganic synthesis; the catalyzed process will make the next major improvement in the utility of the chemistry. Burgess will utilize chiral rhodium complexes to install chirality into the hydroboration process. Mechanistic studies, as well as general examination of the scope and limitation of the developing technology, will be a major emphasis of this new program. This proposal outlines plans to develop rhodium-catalyzed hydroboration reactions for routine use in preparative organic chemistry. Asymmetric hydroborations mediated by various homochiral rhodium-phosphine complexes will be examined for substrates which include unfunctionalized and functionalized prochiral alkenes and a range of chiral allylic/homoallylic compounds. Mechanistic studies performed in parallel with these general synthetic probes will be used to identify ways to better understand the basic chemistry involved as well as to find methods for changing and improving the technology.