Palladium-Dependent Approaches to Enantiomerically Pure Carbocyclic Analogues of Purine Nucleosides

Donald Deardorff博士的研究得到了合成有机化学项目的支持。迪尔多夫是西方学院的化学副教授。他正在研究立体控制制备嘌呤核苷碳环类似物的新方法，这些分子在新药开发中具有重要应用。特别是，新的方法使用有机钯化学将进行审查。该项目的目标是开发新的合成策略，允许方便，立体控制获得嘌呤核苷的饱和和不饱和碳环类似物。使用的策略是重复使用（pi-烯丙基）钯化学。用于展示已开发的合成技术的天然产物靶标包括neplanocin和马兜霉素。将手性引入合成将通过采用酶促反应制备关键起始材料来完成。

The research of Dr. Donald Deardorff is supported by the Synthetic Organic Chemistry Program. Deardorff is an associate professor of chemistry at Occidental College. He is studying new methods for the stereocontrolled preparation of carbocyclic analogues of purine nucleosides, molecules having important applications in the development of new medicines. In particular, new approaches using organopalladium chemistry will be examined. The goal of the project is to develop novel synthetic strategies which permit facile, stereocontrolled access to both saturated and unsaturated carbocyclic analogues of purine nucleosides. Strategies to be used make reiterative use of (pi-allyl)palladium chemistry. Natural product targets used to showcase developed synthetic technologies include neplanocin and aristeromycin. The introduction of chirality into the synthesis will be accomplished by employing enzymatic reactions to prepare key starting materials.