US-Switzerland Cooperative Research on the Effects of Insulin-like Growth Factor I From Dietary Colostrum

该奖项为宾夕法尼亚州立大学教授克雷格·R·鲍姆鲁克到瑞士进行的一次休假研究访问提供了部分支持。他将与伯尔尼大学动物育种研究所的尤尔根·布鲁姆教授以及苏黎世大学内科的E.R.Froesch和J.Zapf教授合作。在研究牛初乳生长因子(IGF-I)对新生小牛的影响方面，他们有共同的兴趣和互补的专业知识。布鲁姆博士在反刍动物的外科和生理学工作方面有丰富的经验；鲍姆鲁克博士在反刍动物乳腺的细胞-分子方面更有成就。他们目前研究的具体目标是确定牛初乳中的饮食IGF-I是否会影响体内的肠道生长，并量化具有生物活性的饮食IGF-I在小牛肠道中的存活率。他们还将调查肠膜上I型和II型IGF受体的存在。最近发现的大量生长因子为理解动物组织发育和生长开辟了一个新的令人兴奋的时代，对农业生产力和人类生物学都有影响。通过检验含有IGF-I的初乳对牛新生儿肠道有有益的生长影响这一假设，这项研究将大大有助于理解初乳和牛奶在肠道中发生的变化。细胞刺激因子的分离和对IGF-I的了解是开发重组生长因子的前提。由于人类和牛的初乳是相同的，这项研究的结果可能会使人类物种受益。

This award provides partial support for a sabbatical research visit to Switzerland by Professor Craig R. Baumrucker of Pennsylvania State University. He will work with Professor Juergen Blum of the Institute of Animal Breeding of the University of Bern and Professors E. R. Froesch and J. Zapf of the Department of Internal Medicine, University of Zurich. They have mutual interest and complementary expertise in studies of the effects of bovine colostrum growth factor (IGF-I) in the neonatal calf. Dr. Blum has extensive experience in surgical and physiological work with ruminants; Dr. Baumrucker is more accomplished in the cellular-molecular aspects of the ruminant mammary gland. The specific objectives of their current research are to determine if dietary IGF-I in bovine colostrum affects intestinal growth in vivo and to quantify the survival of bioactive dietary IGF-I in the intestine of the calf. They will also investigate the occurrence of type I and II IGF receptors in intestinal membranes. The recent discoveries of numerous growth factors has opened a new and exciting era for the understanding of animal tissue development and growth, with implications for agricultural productivity as well as human biology. By testing the hypothesis that colostrum containing IGF-I has beneficial growth effects upon the bovine neonatal intestine, this study will contribute substantially to understanding of what happens to both colostrum and milk in the gut. Isolation of cell stimulatory factors and understanding of IGF-I are prerequisites for development of recombinant growth factors. Since human and bovine colostrum are identical, the results of this study may benefit the human species.