Biomechanical Foundation of Tissue Engineering of Arteries and Veins

这项建议的目的是提高对血管生长和吸收的理解，以响应血管壁上的应力和应变。这项工作包括a)将墙体的结构和力学参数与应力和应变联系起来的实验和理论工作，b)确定决定生长和吸收的因素，以及c)确定应力和生长之间的关系。这项工作将为组织对机械干预的反应方式提供新的基础知识。这项研究在很大程度上依赖于先进的工程技术来描述组织特性，应该为组织工程领域的发展做出贡献。

The goal of this proposal is to improve the understanding of the growth and resorption of blood vessels in response to stresses and strains in the vessel wall. The work includes a) experimental and theoretical work to relate structural and mechanical parameters of the wall to stresses and strains, b) determination of factors that determine growth and resorption, and c) determination of the relationship between stress and growth. The work will provide new fundamental knowledge about the way tissues respond to mechanical intervention. The research strongly depends on advanced engineering techniques to describe tissue characteristics, and should contribute to the developing field of "tissue engineering".