Calcium Ion Resonance In Bone Cells

电磁场已被广泛应用于改善骨骼愈合，但该领域仍存在争议。引起争议的原因之一是，电磁场影响骨细胞的基本机制尚不清楚。这项拟议的项目旨在研究离子回旋共振是否可能是骨功能改变的机制，离子回旋共振导致特定离子的膜运输发生变化。具体地说，这项工作将检验电磁场诱导的回旋加速器共振是否增强了钙离子的传输，以及这种影响是否依赖于外加电场的大小。这是一项基础性研究，可能对最终改进利用电磁刺激促进骨愈合的工程方法具有重要意义。

Electromagnetic (EM) fields have been used quite extensively in an attempt to improve bone healing, but the area remains controversial. One of the reasons for the controversy is that the basic mechanism by which EM fields affect bone cells is not known. This proposed project is to examine whether ion cyclotron resonance, leading to altered membrane transport of specific ions, might be the mechanism of altered bone function. Specifically, this work will examine whether calcium ion transport is enhanced as a result of cyclotrone resonance induced by EM fields, and whether this effect is dependent on the magnitude of the applied fields. This is a fundamental study that may have great significance for eventually improving engineering methods by which EM stimulation is used to improve bone healing.