Organic Chemistry: Effect of Solvents on Organic Reactivity and Selectivity - New Synthetic Methodology

有机合成计划为保罗·A·格里科博士的研究计划的继续提供资金。格里科博士将继续研究溶剂对反应过程的影响，以开发控制反应活性的新模式。这将导致生产灵敏的新方法来生产我们的工农业所需的复杂物质。本研究的主要目的是：(1)进一步探讨2-氮杂龙脑烯的杂环还原反应，(2)开发用于分子间和分子内(3+2)环加成反应的N-取代2-氮杂龙脑烯衍生的N-氧化物的杂环还原工艺。(3)考察3-5M高氯酸锂在乙醚中的Diels-Alder反应和Claisen重排反应。预计的许多研究将是根本性的，以便确定这些潜在有用的新反应的范围和局限性。将在天然产物合成方面进行应用。

The Organic Synthesis Program is funding the continuation of the research program of Dr. Paul A. Grieco. Dr. Grieco will continue his studies of the influence of the solvent on the course of reactions to develop new modes of controlling reactivity. This will lead to the production of sensitive new methods for producing the complex substances needed by our agriculture and industry. The major thrust of this research is: (1) to probe further the heterocycloreversion of 2-azanorbornenes, (2) to develop a heterocycloreversion process for N-oxides derived from N-substituted 2-azanorbornenes for use in intermolecular and intramolecular (3+2) cycloaddition reactions, and (3) to examine Diels-Alder reactions and Claisen rearrangements in 3-5M lithium perchlorate in ether. Many of the studies projected will be of a fundamental nature in order to define the scope and limitations of these potentially useful new reactions. Applications to natural products synthesis will be conducted.