Conference on Biology of Plant and Animal Extracellular Matrix; June 13-19, 1990; Airlie, VA

为支持将于1990年6月9日至13日在弗吉尼亚州沃伦顿附近的Airlie House举行的关于“植物和动物细胞外基质的生物学”的美国细胞生物学夏季会议，请求提供资金。动物细胞外基质曾经主要是从结构上考虑的，现在已知在发育、内稳态、修复、细胞迁移和控制增殖方面发挥着重要作用。在过去的10年里，已经很清楚，植物的细胞外基质(细胞壁)不仅具有许多相同的功能，而且还包含结构/功能上的对应。因此，动物胶原蛋白和植物富含羟脯氨酸的糖蛋白(HRGP)虽然在进化上不相关，但它们代表着类似生物物理问题的相似解决方案，包括这两种基质的很大比例的复杂碳水化合物聚合物也是如此。此外，最近关于植物整合素的存在及其在细胞壁形成中的潜在作用的证据表明，膜-ECM相互作用是跨越大的系统发育距离的机械联系。随着最近研究植物和动物基质识别/组装和基质基因表达调控的新方法和系统的发展，以及许多共同原则可能存在的认识，将研究人员聚集在一起研究植物和动物基质生物学的跨学科会议将是非常及时的。会议将包括一次全体演讲和十次平台会议，分三天半举行，会议设计可容纳150-300人。此外，还将举办下午/晚上的海报会议，旨在鼓励参与者之间最大限度地互动。这是一次及时和重要的会议，很可能带来新的和富有成效的合作和见解。

Funds are requested to support an American Society for Cell Biology Summer Conference on the "Biology of Plant and Animal Extracellular Matrix", to be held from June 9-13, 1990 at the Airlie House near Warrenton, VA. The extracellular matrix of animal cells, once considered mainly in structural terms, is now known to play important roles in development, homeostasis, repair, cell migration, and control of prolifereation. Over the past 10 years it has become clear that the extracellular matrix (cell wall) of plants not only performs many of these same functions, but also contains structural/functional counterparts. Thus, animal collagens and plant hydroxyproline-rich glycoproteins (HRGPs), though un related evolutionarily, represent similar solutions to similar biophysical problems, as do the complex carbohydrate polymers that comprise a large proportion of both kinds of matrix. In addition, recent evidence for the existence of plant intergrins and their potential role in cell wall formation indicates that membrane-ECM interaction are mechanistically linked across large phylogenetic distances. With recent development of new methods and systems for studies of plant and animal matrix recognition/assembly, and regulation of matrix gene expression, and the realization that many common principles are likely to exist, an interdisciplinary conference that brings investigators together to studying plant and animal matrix biology would be very timely. The meeting will include a PLenary Lecture, and ten platform sessions, spread over three and one half days, in a meeting designed to accomodate 150-300 people. In addition, there will be afternoon/evening poster session designed to encourage maximal interaction among participants. This is a timely and important conference, which is likely to lead to new and fruitful collaborations and insights.