PRF/M: Phylogenetic Analysis of Within-species DNA Sequence Data

将开发数学和统计方法来分析和解释来自同一物种不同个体的DNA序列。这项研究的目标是利用这些数据来更好地了解支配遗传进化的过程，特别是突变、重组、基因转换和基因流动。开发的方法将利用物种内DNA序列数据提供的详细信息。将特别注意基因的系统发育关系，如它们的序列所示。研究的总体方法将是将简单问题的简单分析模型与更复杂和现实问题的计算机模拟模型相结合。所开发的方法将应用于现有数据。计划是在理查德·勒文廷的实验室和哈佛大学度过一学期，学习更多关于哪些类型的数据是可用的，并与莱昂丁和他的合作者一起分析他们的数据。//

Mathematical and statistical methods will be developed to analyze and interpret DNA sequences from different individuals of the same species. The goal of the research is to use such data to achieve a greater understanding of processes governing genetic evolution, particularly mutation, recombination, gene conversion and gene flow. The methods developed will take advantage of the detailed information provided by within-species DNA sequence data. Particular attention will be paid to the phylogenetic relationships of genes as indicated by their sequences. The overall approach of the research will be to combine simple analytic models of simple problems with computer simulation models of more complex and realistic problems. The methods developed will be applied to available data. The plan is to spend one semester in Richard Lewontin's laboratory and Harvard University learning more about what kinds of data are available and working with Lewontin and his collaborators on the analysis of their data. //