Electric Dipole Moments of Chiral Ion Pairs

这一女性职业发展研究机会奖是在有机化学的一般领域。韦尔斯利学院化学系的玛格丽特·V·梅里特博士将开发使用电偶极矩测量来检查手性离子对的缔合和结构的方法。离子对在特定溶剂中的离子间几何构型可能与电偶极矩有关。在这项研究中，这两个离子都将有一个不对称的中心：阳离子将是季胺，阴离子将是扁桃酸的盐。电容和电导的测量将在布兰迪斯大学名誉教授欧内斯特·格伦瓦尔德博士的建议下进行，他在这一领域有经验。一名博士后工作者和一名本科生将参与该项目。这一奖项将使梅里特博士能够建立一种新的能力，这是对她之前进行的动力学研究的补充。预计本科生将能够随时参与这些新项目。未来的学生项目将包括新型手性离子对的制备和表征，以及确定单个离子对偶极矩的溶剂依赖性。还将利用红外和质子核磁共振光谱以及X射线结构表征。

This Research Opportunities for Women Career Advancement Award is in the general area of organic chemistry. Dr. Margaret V. Merritt of the Chemistry Department at Wellesley College will develop methods for using electric dipole moment measurements to examine the association and structure of chiral ion pairs. The interionic geometry of ion pairs in particular solvents may be correlated with the electric dipole moment. In this study, both of the ions will have an asymmetric center: the cation will be a quaternary amine and the anion will be the salt of mandelic acid. The capacitance and conductance measurements will be made with the advice of Dr. Ernest Grunwald, emeritus professor of Brandeis University, who has experience in this field. A postdoctoral worker and an undergraduate student will participate in the project. This award will enable Dr. Merritt to establish a new capability that is complementary to kinetic studies she has carried out previously. It is anticipated that undergraduate students will be able to participate readily in these new projects. Future student projects will involve the preparation and characterization of novel chiral ion pairs and determination of the solvent dependence of the dipole moment of a single ion pair. Infrared and proton nmr spectroscopy and X-ray structure characterization will also be utilized.