Effects of Nerve Growth Factor on Nucleus Basalis Magnocellularis Cholinergic Cell Recovery and Function

这项研究将调查一种被称为神经生长因子的大蛋白质促进遭受特定脑损伤的大鼠功能恢复的能力。在对含乙酰胆碱的大脑神经元造成损伤后，将神经生长因子注入大脑。它对脑生化和异常行为的影响将被检查。这项工作很重要，因为它将提供有关特定化学物质如何促进脑损伤后功能恢复的信息。

This research will investigate the ability of a large protein, called nerve growth factor, to promote functional recovery in rats who have undergone specific brain lesions. After producing injury to acetylcholine-containing brain neurons, nerve growth factor will be administered into the brain. Its effects on both brain biochemistry and on abnormal behavior produced by the lesioning will be examined. This work is important because it will provide information about how specific chemicals may work to promote recovery of function after brain damage.