Probing DNA Secondary Structure in vivo with Chiral Metal Complexes

该奖项来自无机、生物无机和有机金属化学项目和生物化学项目，为加州理工学院杰奎琳·k·巴顿博士的工作提供了三年持续资助的第三年。巴顿将与哥伦比亚大学（Columbia University）的劳伦斯·a·查辛（Lawrence A. Chasin）博士合作，评估手性金属配合物作为DNA二级结构探针的实用性。这种金属配合物已被证明在识别具有改变构象的DNA片段方面很有用，例如所谓的z型DNA和十字形DNA。

This award from the Inorganic, Bioinorganic and Organometallic Chemistry Program and the Biochemistry Program provides the third year of a three-year continuing grant to support the work of Dr. Jacqueline K. Barton of the California Institute of Technology. In collaboration with Dr. Lawrence A. Chasin of Columbia University, Dr. Barton will evaluate the usefulness of chiral metal complexes as probes of the secondary structure of DNA. Such metal complexes have proven useful in identifying segments of DNA with altered conformations, such as the so-called Z-DNA and cruciform DNA.