Biochemical Genetics of Host-selective Toxin Biosynthesis

Cochliobolus属的一种植物病原真菌是一项研究的对象，该研究旨在研究由该真菌产生的环肽、寄主选择性毒素的产生的遗传学。有待检验的是，22kb的DNA片段是否是编码参与毒素合成的所有酶的基因簇；这些研究也应该可以深入了解这种真菌属中寄主选择性毒素产生的进化。对植物致病的、经济上重要的真菌产生寄主选择性毒素的研究将采用适合于确定DNA的特定区域是否编码参与环肽毒素合成的几种酶的技术。

A plant pathogenic fungus in the economically-important genus Cochliobolus is the object of a study designed to examine the genetics of production of a cyclic-peptide, host-selective toxin produced by the fungus. To be examined is whether a 22kb stretch of DNA is a gene cluster encoding all of the enzymes involved in synthesis of the toxin; insights into the evolution of host- selective toxin production in this fungal genus should result from these studies, as well. The production of a host-selective toxin by a plant pathogenic, economically important fungus is to be studied by techniques suitable for determining whether a particular region of DNA encodes the several enzymes involved in synthesis of the cyclic-peptide toxin.//