RUI: Behavioral Correlates of Accelerated CNS Sprouting

这一行动是为了支持一所专注于细胞水平的学习和记忆的本科机构的研究。海马体是大脑的一部分，以参与学习和记忆而闻名。Julio Ramirez博士提出的研究将评估皮层损伤后海马体复杂层中发芽的行为意义。评估发芽是否具有行为意义的标准有两个：1)神经再生的时间过程必须与行为恢复的时间过程平行；2)系统地操纵发芽的纤维必须产生伴随的行为变化。由于采用了解剖学和行为学技术，该项目将提供有关中枢神经系统发芽功能意义的基础知识。

This action is to support research at an undergraduate institution which concentrates on learning and memory at the cellular level. The hippocampus is a part of the brain which is known for its involvement in learning and memory. The studies proposed by Dr. Julio Ramirez will evaluate the behavioral significance of sprouting in the intricate layers of the hippocampus after cortical lesions. Two criteria will be used to assess whether the sprouting is behaviorally meaningful: 1) The time course of the reinnervation must parallel the time course of the behavioral recovery; and 2) Systematic manipulation of the sprouted fibers must produce a concomitant change in behavior. Because of the employment of anatomical and behavioral techniques this project will provide fundamental knowledge about the functional significance of sprouting in the central nervous system.