Sleep, Brain Development, and Behavioral Correlates in a Longitudinal Cohort of Children at Risk for ASD

患有自闭症谱系障碍 (ASD) 风险儿童纵向队列的睡眠、大脑发育和行为相关性

• 批准号: 10612375
• 负责人: Annette Estes
• 金额: $ 63.7万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-03 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612375
• 关键词: 10 year old; Accounting; Affect; Affective; Age Months; Anxiety; Autism Diagnosis; Beds; Behavior; Behavior Disorders; Behavior assessment; Behavioral; Biological; Brain; Brain imaging; Cerebrospinal Fluid; Characteristics; Child; Childhood; Circadian Dysregulation; Clinical; Cognition; Cognitive; Communication; Data; Development; Diagnosis; Disease; Environment; Family history of; Follow-Up Studies; Foundations; Funding; Goals; Growth; Health; Hippocampus; Home; Individual; Infant; Intervention; Light; Link; Literature; Longitudinal cohort; Magnetic Resonance Imaging; Maintenance; Medical; Mental disorders; Modeling; Moods; Nature; Neurobiology; Outcome; Parents; Pathogenesis; Pattern; Phenotype; Population; Prevalence; Problem behavior; Public Health; Reporting; Research; Research Priority; Risk; Sampling; Schedule; School-Age Population; Severities; Siblings; Sleep; Sleep Deprivation; Sleep Disorders; Strategic Planning; Structure; Symptoms; Temperature; Testing; United States National Institutes of Health; Vulnerable Populations; actigraphy; adverse outcome; affective disturbance; autism spectrum disorder; autistic children; biopsychosocial; circadian; cohort; comorbidity; design; developmental disease; diaries; early childhood; endophenotype; executive function; follow-up; imaging study; improved outcome; improvement on sleep; infancy; multimodality; neural; neural correlate; novel; psychiatric comorbidity; sleep health; sound; vigilance

Project Summary Children with autism spectrum disorder (ASD) are 2-3 times more likely to suffer from sleep problems than typically developing children. Despite being a high priority population for sleep research, and despite evidence that sleep problems have pervasive negative consequences for health, behavior, mood, and cognition, the increased occurrence and clinical impact of sleep problems in individuals with a family history of ASD is not well understood. This major public health concern is the focus of our application, “Sleep, Brain Development, and Behavioral Correlates in a Longitudinal Cohort of Children at Risk for ASD”. Problems with sleep initiation, circadian timing, and inadequate amount of sleep in a high familial risk (HR) cohort of school-age children are hypothesized to be preceded by altered brain and behavioral development in early childhood. This proposal leverages a recently funded longitudinal follow-up of 7-10 year-old HR children and children with low familial risk for ASD (LR) who have had multiple MRI and behavior assessments since infancy through the NIH Autism Center of Excellence Infant Brain Imaging Study (IBIS). This sample of 300 HR children includes ~100 diagnosed with ASD at 24 months, ~200 without a diagnosis of ASD but with outcomes ranging from typical development to developmental and psychiatric disorders known to occur at high rates in siblings of children with ASD, and 100 LR children currently returning for assessment, including MRI, during school age. A biopsychosocial model of pediatric sleep problems predicts that some combination of biological, environmental, behavioral and psychiatric factors will account for the increased prevalence of sleep problems in ASD, but it is unknown whether sleep problems are familial, endophenotypic, or disorder-specific in this population. We propose to: (1) characterize circadian disturbances, sleep duration, and other sleep parameters in the home using actigraphy, validated by sleep diary, and through parent report of behavioral and medical sleep problems, (2) examine brain growth trajectories (from infancy) associated with sleep problems in school-age, and (3) examine the longitudinal behavioral and developmental trajectories and concurrent behavior associated with sleep problems in school-age. Increased understanding of the neurobiology and developmental characteristics of sleep problems in ASD has important implications for developing novel, developmentally-sensitive sleep interventions which may help to reduce behavioral and health problems exacerbated by sleep problems and improve outcomes in this vulnerable population.

项目摘要 患有自闭症谱系障碍（ASD）的儿童患睡眠障碍的可能性是正常儿童的2-3倍 比通常发育中的儿童更容易出现问题。尽管作为一个高度优先睡眠的人群， 尽管有证据表明睡眠问题对睡眠质量有普遍的负面影响， 健康，行为，情绪和认知，睡眠的发生率和临床影响增加 有ASD家族史的个体的问题还不太清楚。这一重大公共卫生 关注的是我们的应用程序的重点，“睡眠，大脑发育和行为相关性， 有ASD风险的儿童纵向队列”。睡眠的开始，昼夜节律的问题， 在一个高家族风险（HR）的学龄儿童队列中， 假设在儿童早期大脑和行为发育发生改变之前。 该提案利用了最近资助的7-10岁HR儿童的纵向随访， 患有ASD（LR）的低家族风险儿童，他们接受了多次MRI和行为评估 通过NIH自闭症卓越中心婴儿脑成像研究（IBIS）。这 300名HR儿童的样本包括约100名在24个月时被诊断为ASD的儿童，约200名没有 ASD的诊断，但结果范围从典型的发展到发展， 已知ASD儿童的兄弟姐妹中发生率较高的精神疾病，100 LR 目前返回接受评估的儿童，包括学龄期间的MRI。一种生物心理社会学 儿童睡眠问题的模型预测，一些生物，环境， 行为和精神因素将解释睡眠问题的流行率增加， ASD，但尚不清楚睡眠问题是否是家族性的，内在表型的，或疾病特异性的 在这个人群中。我们建议：（1）表征昼夜节律紊乱，睡眠持续时间， 使用活动记录仪在家中的其他睡眠参数，通过睡眠日记和父母进行验证 行为和医学睡眠问题的报告，（2）检查大脑生长轨迹（从 婴儿期）与学龄期睡眠问题相关，以及（3）检查纵向 行为和发育轨迹以及与睡眠相关的并发行为 学龄期的问题。增加对神经生物学和发育的理解 ASD中睡眠问题的特征对于开发新的， 对发育敏感的睡眠干预可能有助于减少行为和健康 睡眠问题加剧的问题，并改善这一弱势群体的结果。