Maintenance and Distribution of Tfm Rats and Mice

睾丸女性化突变(TFM)发生在大鼠、小鼠、牛、黑猩猩和人类身上。这种突变是在X染色体上进行的，所有携带这种突变的男性都表现出对激素和雄激素不敏感的表型。对TFM突变的研究为我们深入了解雄激素的作用方式，特别是激素与中枢神经系统蛋白质之间的相互作用提供了线索。GW小组维护着唯一已知的TFM大鼠群体，是研究界的宝贵资源。

The testicular feminization mutation (Tfm) occurs in rats, mice, cattle, chimpanzee and humans. The mutation is carried on the X- chromosome and all males carrying this mutation exhibits the phenotype which is the insensitivity to the hormone, androgens. Studies of Tfm mutation have provided us with insights on the mode of action of androgens, particularly the interaction between the hormone and CNS proteins. The GW group maintains the only known colony of Tfm rats and serves as an invaluable resource for the research community.