Transition Metal Reagents in Organic Synthesis

施瓦茨博士的研究主要集中在两个领域。首先，过渡金属配合物将结合到氧化物载体上，然后通过锚定来防止配位不饱和物种聚集，稳定过渡金属的高氧化态，并作为可变配体，其中路易斯酸和羟基位点的碱度和可用性可以调整。这些配合物将通过动力学、结构和合成研究进行探索。第二，研究早期过渡金属配合物作为新型合成试剂。重点将是利用氧化钨化合物催化将羟基酸转化为内酯。还将进行氧化结合锆的制备和与可溶性类似物的比较。有了这个奖，化学分部的合成有机项目将支持普林斯顿大学化学系的杰弗里·施瓦茨博士的研究。本研究是在合成方法学的一般领域，主要集中在有机合成中的过渡金属试剂领域。该项目的目标是寻找能够在温和条件下以高产量在有机基质上进行特定转化的金属配合物。

Dr. Schwartz's research is focused on two areas. First, transition metal complexes will be bound to an oxide support which will then be a ligand environment for them by anchoring to prevent clustering of coordinatively unsaturated species, stabilizing high-oxidation states of the transition metal, and acting as a variable ligand in which basicity and availability of Lewis acid and hydroxylic sites can be adjusted. These complexes will be probed by kinetic, structural and synthetic studies. Second, early transition metal complexes will be studies for use as new synthetic reagents. The focus will be on the catalytic conversion of hydroxy acids into lactones by use of oxotungsten compounds. The preparation of oxide-bound zirconium species and comparisons to soluble analogs will also be carried out. %%% With this award, the Synthetic Organic Program of the Chemistry Division will support the research of Dr. Jeffry Schwartz of the Department of Chemistry at Princeton University. The research is in the general area of synthetic methodology and is focused on the areas of transition metal reagents in organic synthesis. The goals of the project are to find metal complexes which can perform specific transformations on organic substrates under mild conditions and in high yield.