A Membrane-Stabilized Preferential Crystallization Process

手性化合物的外消旋混合物可以用直接优先结晶技术进行光学拆分。该方法是基于从过饱和溶液中选择性地将对映体沉积到为此目的提供的光学纯种子晶体上。该技术具有固有的优势，因为它避免了手性辅助剂和额外的过程化学，这些都是生产光学纯药物的其他方法的特点。虽然择优结晶已被成功地应用于合成几种重要的手性化合物，但如果不是因为选择性结晶可能是一个难以大规模控制的过程，它无疑会得到更广泛的应用。建议研究膜稳定优先结晶用于立体异构体分离的可行性和潜在的益处。在新的工艺中，使用选择性膜来限制单个对映体和晶种，以提高结晶的稳定性，从而提高工艺的可靠性和效率。

Racemic mixtures of chiral compounds that crystallize as conglomerate mixtures may be optically resolved using the technique of direct preferential crystallization. The method is based on the selective deposition of enantiomers from supersaturated solution onto optically pure seed crystals provided for this purpose. The technique has inherent advantages in its avoidance of the chiral auxiliaries and additional process chemistry that are characteristic of other methods for producing optically pure drugs. While preferential crystallization has been applied successfully to produce several important chiral compounds, it would undoubtedly be more widely used were it not for the fact that selective crystallization can be a difficult process to control on the large scale. It is proposed to examine the feasibility and potential benefits of membrane-stabilized preferential crystallization for stereoisomer separations. In the novel process, selective membranes are used to confine individual enantiomers and seed in such away as to enhance the stability of crystallization and thereby to improve process reliability and efficiency.