Stereochemical Purification of an Anti-Inflammatory Drug in an Enzyme Membrane Reactor

酶膜反应器中抗炎药物的立体化学纯化

• 批准号: 8660957
• 负责人: Stephen Matson
• 金额: $ 3.95万
• 依托单位: Sepracor Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-02-01 至 1987-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8660957&HistoricalAwards=false
• 关键词: Stereochemical; Purification; Anti; Inflammatory; Drug

The sale price of drugs is strongly affected by the cost of purifying the product - i.e. separating the desired chemical from the reaction medium in which it is produced. This project is a study of a bioreactor that combines the production and separation stages in one unit and thus could greatly decrease final costs to consumers. Some of this high cost is due to the increased complexity of new drugs, often very complicated molecules which may exist in more than one configuration (isomer). Of these, often only one configuration has the desired properties and separating them from each other results in additional difficulties over and above those encountered when separating different compounds from each other. The configurations to be looked at are hollow-fiber modules where the enzymes (the biocatalysts) are immobilized and product is continuously removed. This has the advantage also that product concentration does not build up which normally inhibits enzyme activity. The PIs plan to measure enzyme activity and stereoselectivity and to operate a prototype reactor in this Phase I work. They are well qualified to do the research and the facilities are adequate. Funding is recommended.

药品的销售价格受药品价格的影响很大。 纯化产物-即将所需的化学品与 它在其中产生的反应介质。 这个项目是一个 生产与分离相结合的生物反应器的研究 在一个单位的阶段，从而可以大大降低最终成本， 消费者 这种高成本的部分原因是增加了 新药的复杂性，通常是非常复杂的分子， 可能存在一种以上的构型（异构体）。 其中， 通常只有一种结构具有所需的性能 将它们彼此分开会导致额外的 除了分离时遇到的困难之外， 不同的化合物。 要考虑的配置是中空纤维模块， 酶（生物催化剂）被固定化， 不断被移除。 这也有一个优点， 浓度不会增加，这通常会抑制酶 活动 PI计划测量酶活性， 立体选择性，并在此操作原型反应器 第一阶段工作。 他们很有资格做研究， 设施足够。 建议提供资金。