U.S.-Brazil Cooperative Research: Isolation of Novel NaturalCompounds from Brazilian Species

该奖项支持在天然化合物化学方面的合作研究。这项研究将由弗吉尼亚理工学院和州立大学的大卫·金斯顿博士与巴西弗卢米嫩塞联邦大学的阿方斯·克莱科姆合作进行。本工作旨在从巴西植物和海洋生物中分离和鉴定新的化合物。植物和海洋生物都已被证明是新型抗肿瘤药物的重要来源，预计对巴西植物和海洋物种的持续搜索将产生更多有用的化合物。在巴西的这项工作将由克莱科姆博士执行，他将进行海洋和陆地采集，并进行初步的生物系统和分离。在美国的工作将由金斯顿教授和他的团队进行，包括生物活性成分的最终纯化和结构阐明。这个项目对Kelecom博士的主要好处是，它使他能够获得必要的设备和专业知识，以完成分离和结构鉴定。金斯顿博士的主要好处是，它让他有机会接触到更多的植物和海洋生物，以分离天然化合物。

This award supports collaborative research on the chemistry of natural compounds. It will be conducted by Dr. David Kingston of the Virginia Polytechnic Institute & State University in cooperation with Alphonse Kelecom of the Federal University in Fluminense, Brazil. This work is aimed at the isolation and structure elucidation of novel chemical compounds from Brazilian plants and marine organisms. Both plants and marine organisms have proved important sources of novel antitumor agents, and it is expected that a continued search of Brazilian flora and marine species will yield additional useful compounds. The work in Brazil will be carried out by Dr. Kelecom, who will make both marine and terrestrial collections and perform preliminary bioassys and isolations. The work in the U.S.A. will be carried out by Professor Kingston and his group, and will include the final purification of bioactive constituents and their structure elucidation. The major benefit of this project to Dr. Kelecom is that it gives him access to the necessary equipment and expertise to complete the isolation and structure elucidation. The major benefit to Dr. Kingston is that it gives him access to an enlarged group of plants and marine organisms for the isolation of natural compounds.