Base Stable and Composite ZrO2 Ceramic Supports for HPLC

这一协作奖是在材料化学和化学加工倡议下颁发的，由化学和化学及热系统部门提供支持。这项研究的目标是开发一种技术先进的单分散、宽孔、高内表面积、机械和pH稳定的多孔氧化锆颗粒，用于分离科学。新型陶瓷材料将符合目前和未来生物化学材料下游加工的需要。根据材料所需的几何、机械和化学特性，将对颗粒进行优化，以完成各种分离任务。优化将包括颗粒表面的化学修饰以及高、低温处理步骤。在合成和表面处理之后，颗粒将在各种最终用途中进行表征和评估。这将是一个反复的过程。%这项研究将开发一种基于氧化锆微球的多面载体家族，用于分析和制备规模的层析以及流态床分离。这项研究的目的是通过用氧化锆取代二氧化硅来克服与二氧化硅载体相关的主要问题，并开发这种基质独特的分离化学。

This collaborative award, made under the Materials Chemistry and Chemical Processing Initiative is supported by the Divisions of Chemistry and Chemical and Thermal Systems. The goal of the research is the development of a family of technically advanced monodisperse, wide-pore, high internal surface area, mechanically and pH-stable, porous zirconia particles for use in separations science. Novel ceramic materials will be made that conform to the needs of the current and future downstream processing of biochemical materials. Based on the required geometric, mechanical and chemical characteristics of the materials, the particles will be optimized to accomplish a wide variety of separation tasks. Optimization will include chemical modification of particle surfaces and high and low temperature processing steps. Following synthesis and surface treatment, particles will be characterized and evaluated in a variety of end uses. This will be an iterative process. %%% This research will develop a multi-faceted family of supports based on porous microspheres of zirconia to be used in both analytical and preparative-scale chromatography and in fluidized bed separations. The objective of the research is to overcome the major problems associated with silica-based supports by replacing silica with zirconia and to exploit the unique separations chemistry of this substrate.