U.S.-China Cooperative Research (Molecular Biology): ScaledProtein Folding

这一建议解决了一个最紧迫的问题， 分子生物学今天-如何预测的折叠 球状蛋白质的氨基酸序列。在 与Y.H.合作中国吉林大学的王， 克里彭医生会核实，分析和扩展初步的 观察到天然蛋白质构象可以是 用傅立叶和其他类似的方法来描述， 转换，并且这些转换与 蛋白质的氨基酸序列 后续目标是 开发一种算法，用于搜索低能构象 用傅立叶系数作为主要的 变量 搜索方法是否相当于分子 动力学，某种局部或全局能量最小化， 或蒙特卡罗程序，该方法将首先操纵 构造的大尺度特征， 调整小尺度细节。 这两者之间的关系 蛋白质折叠机制的程序和理论， 探讨了 这个项目汇集了两位科学家，一位来自中国， 一个来自美国，他们有着共同的兴趣和小说， 解决分子生物学中的一个重要问题。

This proposal addresses one of the most pressing questions in molecular biology today - how to predict the folding of globular proteins from their amino acid sequence. In collaboration with Y.H. Wang of Jilin University in China, Dr. Crippen will verify, analyze and extend preliminary observations that native protein conformations can be described very compactly in terms of Fourier and other such transforms, and that these transforms correlate strongly with the protein's amino acid sequence. The subsequent goal is to develop an algorithm for searching for low energy conformations of a protein using Fourier coefficients as the primary variables. Whether the search method amounts to molecular dynamics, some kind of local or global energy minimization, or Monte Carlo procedure, the method would first manipulate the large scale features of conformation and then later adjust the small scale details. The relation between this procedure and theories of protein folding mechanisms would be explored. This project brings together two scientists, one from China, and one from the US, who share a common interest and a novel approach to an important problem in molecular biology.