Grant for Exploratory Research: ESR Imaging Without DC Magnetic Field Gradients

这项研究由化学部的分析和表面化学计划支持，旨在设计和制造用于电子自旋共振(ESR)成像的新型仪器。将采用射频信号输入的程序定相，而不是磁场梯度。还将使用比通常用于ESR光谱分析的频率更低的频率，从而减少样品加热的问题。如果成功，这项探索性研究拨款应该会带来与其他情况下完全不同的ESR成像仪器。磁共振成像极大地改进了诊断医学。由于产生信号的仪器和基本困难，电子自旋共振成像没有产生核磁共振的影响。在这项研究中，在化学系分析和表面化学计划的支持下，将建立和研究一种产生电子自旋图像的新方法，该方法可能克服以前发现的几个问题。这种探索性研究拨款被认为是高风险的，但其回报(在不烘焙研究对象的情况下常规地在原位成像自由基的能力)使风险是值得的。

This research, supported by the Analytical and Surface Chemistry Program in the Chemistry Division, seeks to design and build novel instrumentation for Electron Spin Resonance (ESR) imaging. Programmed phasing of radio frequency signal inputs rather than magnetic field gradients will be employed. Lower frequencies than are commonly employed for ESR spectrometry will also be employed, reducing the problems of sample heating. If successful, this Grant for Exploratory Research should lead to radically different ESR imaging instrumentation than would otherwise be available. %%% Magnetic Resonance Imaging has profoundly improved diagnostic medicine. Electron Spin Resonance imaging has not had the impact of Nuclear Magnetic Resonance, due to instrumental as well as fundamental difficulties in generating signals. In this research, supported by the Analytical and Surface Chemistry Program in the Chemistry Division, a novel means of generating electron spin images which may overcome several of the previously identified problems will be built and studied. This Grant for Exploratory Research is considered to be high risk, but the reward (the ability to routinely image free radicals in situ without roasting the object studied) makes the risk worthwhile.