Advances in Peptide Synthesis: Exploiting Underutilised Functional Groups

将与治疗相关的肽类转化到临床通常受到化学家有效和可持续地合成这些复杂生物分子的能力的限制。该项目旨在开发用于制备设计肽的新工具，这些设计肽受到天然肽序列中未充分利用的反应基团的广泛启发。预期成果包括澳大利亚社区的健康和经济效益，包括：一类有前途的抗生素肽天然产物类似物的第一种方法，开发一种温和的电化学方法来修饰肽，以及生产一种新的氨基酸库，用于并入潜在的抗生素先导化合物。

The translation of therapeutically-relevant classes of peptides to the clinic is often limited by chemists' ability to synthesise these complex biomolecules efficiently and sustainably. This project aims to develop new tools for the preparation of designer peptides that are broadly inspired by an underutilised reactive group found in naturally-occurring peptide sequences. Expected outcomes encompass health and economic benefits for the Australian community, including: the first approach to a class of promising antibiotic peptide natural product analogues, the development of a mild electrochemical approach to peptide modification, and the production of a library of novel amino acids for incorporation into potential antibiotic leads.