US-Poland Research on Chemistry of Core-Modified Porphryins

美国-波兰研究项目的目标是由加州大学戴维斯分校的Alan L. Balch博士和波兰弗罗茨瓦夫大学化学研究所的Lechoslaw Latos-Grazynski博士合作，是探索核修饰卟啉的合成和配位性质-卟啉是指一个或多个吡咯氮被改变，特别是被不同的杂原子取代的卟啉。研究人员预计，这些配体将稳定金属离子在低氧化态和平面，而不是四面体几何。我们将研究金属离子在这些不寻常环境中的反应性。他们将继续研究单硫卟啉的配位特性，特别是它们的（正式的）Ni(I)和Pd(I)配合物。结果有望提高我们对金属生物化学某些方面的理解，并可能产生配合物，作为有机分子烷基化或氧化的良好催化剂。该化学项目通过使美国和东欧的领先专家在共同感兴趣和能力强的领域结合互补的人才和汇集资源，实现了推进科学知识的计划目标。

The objective of this US-Poland research project between Dr. Alan L. Balch of the University of California-Davis and Dr. Lechoslaw Latos-Grazynski of the Institute of Chemistry, University of Wroclaw, Poland, is to explore the synthesis and coordination properties of core-modified porphyrins -- porphyrins which one or more of the pyrrole nitrogens has been altered, particularly by replacement with a different heteroatom. The researchers anticipate that these ligands will stabilize metal ions in low oxidation states and in planar, rather than tetrahedral geometry. The reactivity of the metal ions in these unusual environments will be examined. They will continue their studies of the coordination properties of monothiaporphyrins, particularly their (formal) Ni(I) and Pd(I) complexes. Results are expected to improve our understanding of certain aspects of metallobiochemistry and may yield complexes that are good catalysts for alkylation or oxidation of organic molecules. This project in chemistry fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool resources in areas of strong mutual interest and competence.