U.S.-Poland Biophysics Research on Design of Peptide Mimetics

美国的目标是-波兰的研究项目之间的博士。 Peter A.科尔曼博士是美国宾夕法尼亚大学药学院的 加利福尼亚州弗朗西斯科中心和 华沙大学，波兰，是进行理论 设计肽类似物的计算， 蛋白质HIV蛋白酶、嗜热菌蛋白酶和 弹性蛋白酶 这种酶的抑制剂的成功设计， 如果它被证明有治疗价值，可以用来对付 艾滋病病毒。 相同类型的设计可以转移到 其它胆固醇基蛋白酶如肾素抑制剂， 提供治疗高血压的方法。 丝氨酸的选择性抑制 蛋白酶如人白细胞弹性蛋白酶作为潜在药物 对抗肺气肿或其他退行性疾病， 使用相同的原则。 这个生物物理学项目实现了以下计划目标： 促进科学知识的发展， 美国和东欧将联合收割机互补 在共同感兴趣的领域汇集人才和资源， 能力。

The objective of this U.S.-Poland research project between Dr. Peter A. Kollman of the School of Pharmacy, University of California, San Francisco Center, and Dr. Piotr Cieplak of the University of Warsaw, Poland, is to carry out theoretical calculations to design peptide analogs that have the potential to be excellent inhibitors of the proteins HIV protease, thermolysin and elastase. The successful design of an inhibitor for this enzyme, should it prove of therapeutic value, could be used against the AIDS virus. The same type of design could be transferred to the inhibitor of other aspartyl proteases such as renin, which would provide therapy against hypertension. Selective inhibition of serine proteases such as human leucocyte elastase as a potential drug against emphysema or other such degenerative diseases might be achieved using the same principles. This project in biophysics fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool resources in areas of strong mutual interest and competence.