Development of Selective Connectivity in a Simple Nervous System

墨菲博士进行这项研究的目的是 了解突触在突触形成过程中是如何稳定的 神经系统的重组。 突触组装过程 是一个动态的过程，涉及突触前和突触后细胞。 在上一个资助期间，墨菲博士收集了显着的 结果表明，强度和短期塑性 突触可以由突触后细胞控制。 墨菲医生 现在将集中研究突触后神经元的作用 突触组装过程中的细胞。 他将利用 电生理技术描述短期和长期 不断改变的突触可塑性。 在 此外，将使用药理学工具来阻断神经发生， 或神经活动来探索 潜在的突触稳定和不稳定。 最后，博士。 墨菲将使用计算工具来探索 神经元突触重排的过程 获得的结果 这项研究将大大增加我们对 在突触的组装中涉及相互作用。*

The goal of the research to be performed by Dr. Murphey is to understand how synapses are stabilized during synaptic rearrangement in the nervous system. The synaptic assembly process is a dynamic one involving both the pre- and post synaptic cells. During the previous funding period, Dr. Murphey gathered remarkable results suggesting that the strength and short term plasticity of synapses can be controlled by the postsynaptic cell. Dr. Murphey will now concentrate his studies on the role of the postsynaptic cell in the process of synapse assembly. He will utilize electrophysiological techniques to describe short and long term plasticity at synapses that are constantly being altered. In addition, pharmacological tools will be used to block neurogenisis or neural activity in an effort to explore the mechanisms underlying synapse stabilization and destabilization. Finally, Dr. Murphey will use computational tools to explore the consequences of synaptic rearrangement for circuit function. Results obtained from this study will add significantly to our knowledge of what interactions are involved in the assembly of synapses.***