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Re-sensitization of immune checkpoint therapy resistant cancers to cytotoxic T-lymphocyte mediated killing

Re-sensitization of immune checkpoint therapy resistant cancers to cytotoxic T-lymphocyte mediated killing
免疫检查点疗法耐药性癌症对细胞毒性 T 淋巴细胞介导的杀伤重新敏感
批准号:
412967
负责人:
Caumanns Joseph J
金额:
$9.83万
依托单位国家:
加拿大
项目类别:
Fellowship Programs
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-10-01 至 2022-10-01

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中文摘要
翻译
细胞毒性T淋巴细胞在通过免疫系统消除癌细胞中具有关键作用,但其抗癌功效受到免疫检查点的严重阻碍。免疫检查点抑制(ICI)可以重新激活抗癌免疫,
英文摘要
Cytotoxic T-lymphocytes have a key role in elimination of cancer cells by the immune system, but their anti-cancer efficacy is severely hampered by immune checkpoints. Immune checkpoint inhibition (ICI) can re-activate anti-cancer immunity and provides du
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