Chemical Factors in the Brain Involved in Ingestive Behavior

身体的重要功能由脑干的复杂机制控制，其中包括激素和神经递质物质。作为这一奖项的结果，迈尔斯博士将进行的研究将涉及导致饥饿、进食行为、饱腹感、实验性厌食症、体温调节、体温过高和体温过低的过程。将特别强调饥饿机制和温度调节机制之间的相互作用。在具体的实验中，将研究一种新发现的蛋白质因子-巨噬细胞炎症蛋白1(MIP-1)的功能。这种物质是一种强有力的内源性因素，在下丘脑水平上直接参与了饥饿和温度的调节。这些研究将集中在大脑对MIP-1的敏感性，包括温度和摄食的变化，以及MIP-1与其他神经递质的相互作用，这些神经递质参与这些功能的生理调节。这项研究将为大脑中的激素和递质如何调节维持生命的调节功能提供基本的科学信息。

Vital functions of the body are controlled by complex mechanisms of the brainstem, which involve both hormones and neurotransmitter substances. The research to be performed by Dr. Myers as a result of this award will deal with processes responsible for hunger, the act of feeding, the condition of satiety, experimental anorexia, the regulation of body temperature, hyperthermia and hypothermia. Special emphasis will be placed on the interaction between mechanisms of hunger and of temperature regulation. In specific experiments, the function of a newly discovered protein factor called macrophage inflammatory protein 1 (MIP-1 ) will be studied. This substance is a potent endogenous factor which has been directly implicated in the regulation of hunger and temperature at the level of hypothalamus. The studies will focus on brain sensitivity to MIP- 1 in terms of changes in temperature anf feeding, and the interaction of MIP-1 with other neurotransmitters that are known to be involved in physiological regulation of these functions.This research will contribute fundamental scientific information about how hormones and transmitters in the brain can modulate life-sustaining regulatory functions.