Understanding the link between sociocultural and biological factors to brain health across race & ethnicity in midlife

项目概要/摘要 美国的黑人和拉丁裔经历了更大的大脑老化，患阿尔茨海默病的风险增加， 相关痴呆症（ADRD）比白人。风化假说，最初提出来解释过早 面临压力、社会不利地位、结构性种族主义的黑人妇女的健康状况下降， 歧视，可能有助于解释更快的大脑老化和种族/民族差异，在ADRD在晚年， 老年黑人和拉丁裔确定干预措施的潜在目标，以减少大脑健康的差异 对于迅速扩大的老龄人口来说，多样化的老龄人口至关重要。生物 老化，随着年龄的增长而发生的系统完整性的逐渐丧失，被认为是一个可修改的过程 调解这种健康不平等。此外，先前的研究表明，ADRD病理早在中年就开始了， 因此，在中年评估这些关系至关重要，这一时期可能是最关键的时期 干预这项建议利用了从种族歧视机制的后代研究中收集的数据， ADRD的差异-一项对不同种族/民族的中年成人进行MRI、血液检查的纵向研究 分析和访谈数据。本K99/R00建议书的主要目标是确定 在不同种族/民族的中年人中，晚期生物衰老与MRI生物标志物之间的关系， 描述生命过程社会经济地位（SES）、高级生物老化和MRI之间的联系 衰老和ADRD的生物标志物。 这个K99/R00提案为专注于了解 将环境，社会文化和生物因素与大脑健康差异联系起来的因果途径 种族/民族。总之，研究和培训计划将使申请人（1）发展专业知识，使用 多种方式来了解生物和大脑老化; 2）掌握因果推理建模，具有特殊的 强调按种族/族裔比较关系的多群体分析; 3）扩大 中年健康的社会文化因素; 4）在理论和相关研究方面建立坚实的基础 to cultural文化influences影响on brain脑health健康.这些经验将补充申请人现有的强大的 认知神经科学和认知老化的背景。这项研究的结果可能指向新的来源， 脑老化和ADRD中的种族/民族差异可能是未来的干预目标，并有助于验证 在中等收入国家的不同社区中监测或预防ADRD的可获得的基于血液的目标 老年人。

PROJECT SUMMARY/ABSTRACT Black and Latinx in the U.S. experience greater brain aging and increased risk for Alzheimer’s disease and related dementias (ADRD) than Whites. The weathering hypothesis, originally proposed to explain the premature decline of health experienced by Black women exposed to stress, social disadvantage, structural racism, and discrimination, may help explain the faster brain aging and racial/ethnic disparities in ADRD in late life among older Black and Latinx people. Identifying potential targets for interventions to reduce disparities in brain health in the diverse aging population is of critical importance to the rapidly expanding aging population. Biological aging, the progressive loss of system integrity that occurs as we age is proposed as a modifiable process mediating this health inequality. Further, previous studies show that ADRD pathology begins as early as midlife, thus, it is critical to evaluate these relationships in midlife, a time that may be the most critical period for intervention. This proposal leverages data collected from the Offspring Study of Mechanisms for Racial Disparities in ADRD—a longitudinal study of racially/ethnically diverse middle-aged adults with MRI, blood assays, and interview data. The primary goals of this K99/R00 proposal are to determine the relationship between advanced biological aging and MRI biomarkers in racially/ethnically diverse middle-aged adults and to characterize the links between lifecourse socioeconomic status (SES), advanced biological aging, and MRI biomarkers of aging and ADRD. This K99/R00 proposal lays the foundation for an independent research career focused on understanding the causal pathways linking environmental, sociocultural, and biological factors to disparities in brain health across race/ethnicity. Together, the research and training plans will allow the applicant to (1) develop expertise in using multiple modalities to understand biological and brain aging; 2) master causal inference modeling, with special emphasis on multigroup analyses that compare relationships by race/ethnicity; 3) broaden knowledge base of health-defining sociocultural factors in midlife; and 4) establish a strong foundation in theory and research related to cultural influences on brain health. These experiences will supplement the applicant’s strong existing background in cognitive neuroscience and cognitive aging. Results from this study may point to new sources of racial/ethnic disparities in brain aging and ADRD that could be future targets for intervention, and help to validate accessible, blood-based targets for monitoring or prevention of ADRD among diverse communities of middle- aged adults.