Understanding the link between sociocultural and biological factors to brain health across race & ethnicity in midlife

了解社会文化和生物因素与跨种族大脑健康之间的联系

• 批准号: 10429375
• 负责人: Indira Turney
• 金额: $ 13.07万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10429375
• 关键词: Adult; Age; Aging; Alzheimer disease prevention; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Biological; Biological Aging; Biological Assay; Biological Factors; Biological Markers; Black Populations; Black race; Blood; Cerebrovascular Disorders; Cerebrovascular system; Childhood; Chronology; Cognitive aging; Communities; DNA Methylation; Data; Discrimination; Disease Marker; Education; Elderly; Epigenetic Process; Ethnic Origin; Ethnic group; Exposure to; Foundations; Future; Gender; Goals; Health; Hippocampus (Brain); Infarction; Intervention; Interview; Latinx; Latinx population; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Mentors; Modality; Modeling; Monitor; Nerve Degeneration; Occupations; Parents; Participant; Pathology; Pathway interactions; Pattern; Process; Race; Research; Research Training; Rest; Socioeconomic Status; Source; Statistical Data Interpretation; Stress; Structural Racism; System; Testing; Thick; Time; Training; Weather; White Matter Hyperintensity; aging brain; aging population; base; black women; brain health; brain magnetic resonance imaging; career; cognitive neuroscience; cohort; critical period; design; disparity reduction; ethnic diversity; experience; family structure; health inequalities; knowledge base; magnetic resonance imaging biomarker; methylation biomarker; middle age; novel; offspring; premature; racial and ethnic; racial and ethnic disparities; racial disparity; racial diversity; sex; social; social culture; social disadvantage; stressor; theories

PROJECT SUMMARY/ABSTRACT Black and Latinx in the U.S. experience greater brain aging and increased risk for Alzheimer’s disease and related dementias (ADRD) than Whites. The weathering hypothesis, originally proposed to explain the premature decline of health experienced by Black women exposed to stress, social disadvantage, structural racism, and discrimination, may help explain the faster brain aging and racial/ethnic disparities in ADRD in late life among older Black and Latinx people. Identifying potential targets for interventions to reduce disparities in brain health in the diverse aging population is of critical importance to the rapidly expanding aging population. Biological aging, the progressive loss of system integrity that occurs as we age is proposed as a modifiable process mediating this health inequality. Further, previous studies show that ADRD pathology begins as early as midlife, thus, it is critical to evaluate these relationships in midlife, a time that may be the most critical period for intervention. This proposal leverages data collected from the Offspring Study of Mechanisms for Racial Disparities in ADRD—a longitudinal study of racially/ethnically diverse middle-aged adults with MRI, blood assays, and interview data. The primary goals of this K99/R00 proposal are to determine the relationship between advanced biological aging and MRI biomarkers in racially/ethnically diverse middle-aged adults and to characterize the links between lifecourse socioeconomic status (SES), advanced biological aging, and MRI biomarkers of aging and ADRD. This K99/R00 proposal lays the foundation for an independent research career focused on understanding the causal pathways linking environmental, sociocultural, and biological factors to disparities in brain health across race/ethnicity. Together, the research and training plans will allow the applicant to (1) develop expertise in using multiple modalities to understand biological and brain aging; 2) master causal inference modeling, with special emphasis on multigroup analyses that compare relationships by race/ethnicity; 3) broaden knowledge base of health-defining sociocultural factors in midlife; and 4) establish a strong foundation in theory and research related to cultural influences on brain health. These experiences will supplement the applicant’s strong existing background in cognitive neuroscience and cognitive aging. Results from this study may point to new sources of racial/ethnic disparities in brain aging and ADRD that could be future targets for intervention, and help to validate accessible, blood-based targets for monitoring or prevention of ADRD among diverse communities of middle- aged adults.

项目总结/文摘