Interrogating protein hydration by terahertz time-domain spectroscopy

用太赫兹时域光谱研究蛋白质水合作用。该项目旨在开发先进的太赫兹时域光谱（THz-TDS）技术，以了解蛋白质与溶液中辅料的相互作用如何改变其周围的水合层，以及这如何影响粘度和稳定性等特性。THz-TDS可以检测蛋白质周围重叠的扩展水合层，揭示水环境中蛋白质相互作用和蛋白质行为的新知识。预期的结果是使用THz-TDS来更好地了解蛋白质（如单克隆抗体）在高浓度溶液中如何相互作用，从而制造出更好的药物。

Interrogating protein hydration by terahertz time-domain spectroscopy. This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing new knowledge in protein-protein interactions and protein behaviour in an aqueous environment. The intended outcome is to use THz-TDS to better understand how proteins such as monoclonal antibodies interact in high concentration solutions, and in doing so make better medicines.