Improvements in Aerobic Bioreactor Cell Capacity through FacFacilitated Oxygen Transport Agents

Aquanautics公司合成和表征 氧结合复合物。 这些化合物旨在 对于商业应用， (for例如，饮料氧气过滤器）到低功率氧气 生产（例如，“人工鳃”）。 这 项目是利用这些化合物作为代理， 促进氧流到酿酒酵母（Baker's 酵母）和哺乳动物细胞。 这项建议有两个目的。 一是展示 原生动物和后生动物的文化是兼容的 过渡金属结合化合物。二是 证明这种添加剂将使 维持较高的细胞密度或较高的细胞 代谢率 如果这项研究成功， 可以更经济地生产细胞遗传产品。

Aquanautics Corporation synthesizes and characterizes oxygen binding complexes. These compounds are intended for commercial applications ranging from oxygen removal (for example, beverage oxygen filters) to low power oxygen production (for example, the "artificial gill"). This project is to exploit some of these compounds as agents to facilitate oxygen flux to Saccharomyces cerevisae (Baker's yeast) and mammalian cells. The objective of this proposal is twofold. One is to show that protozoan and metazoan cultures are compatible with transition metal binding compounds. The other is to demonstrate that such an additive will enable the maintenance of higher cell densities or higher cell metabolism rates. If this research is successful, the cell genetic products can be produced more economically.