PRF: Origin and Maintenance of Pericentric-inversion Polymorphism in the Deer Mouse, Peromyscus maniculatus

本研究的主要目的是评估普通鹿鼠（Peromyscus maniculatus） 6号染色体周中心倒位共同区域内的限制性位点和DNA序列变异，并确定特定DNA单倍型与该染色体的三种变体之间是否存在连锁不平衡。这些数据将用于评估马齿虎和相关鹿鼠种锡肯氏鹿鼠和奥雷亚斯鹿鼠中广泛存在的周中心倒置多态性的起源（单系或趋同）和维持（选择或反复突变）的两种可选假设。样本将包括从北美自然种群中收集的鹿鼠。马齿虎（P. maniculatus）的顺心倒转系统为检验果蝇顺心倒转系统的遗传假说和进化原理的普遍适用性提供了一个理想的哺乳动物模型。

The primary objectives of this research are to assess restriction-site and DNA-sequence variation within the region common to pericentric inversions of chromosome 6 in the common deer mouse (Peromyscus maniculatus), and to determine whether linkage disequilibrium exists between specific DNA haplotypes and each of the three morphs of this chromosome. These data will be used to evaluate two alternative hypotheses for the origin (monophyletic or convergent) and maintenance (selection or recurrent mutation) of the widespread pericentric-inversion polymorhisms in P. maniculatus and the related deer mouse species P. sitkensis and P. oreas. The sample will include deer mice collected from natural populations throughout North America. The pericentric-inversion system of P. maniculatus represents an ideal mammalian model to test the general applicability of the genetic hypotheses and evolutionary principles derived from the paracentric-inversion system of the fruit fly Drosphila pseudoobscura.