RAS Proto-Oncogene Activity in Corpus Lutem Function

最近发现，在大鼠中， 卵巢中含有一种特殊的蛋白质，K-ras p21蛋白 反映了黄体分泌的模式 黄体此外，当针对这种蛋白质的抗体被 在离体条件下，孕酮进入黄体细胞， 这些细胞显著减少，从而表明， 这种蛋白质在产生/分泌 黄体细胞分泌孕酮。这是我们的目标 建议确定K-ras p21 蛋白质影响黄体孕酮分泌， 这种p21蛋白是否在其他细胞的分泌中起作用， 黄体中的激素K-ras p21蛋白存在于所有 哺乳动物细胞因此，拟议研究的结果将 对卵巢激素的认识产生重大影响 分泌机制，以及我们对 所有的哺乳动物细胞都会对激素和生长因子做出反应。

It was recently discovered that, in the rat, the amounts of a particular protein, the K-ras p21 protein, contained in the ovary mirror the pattern of secretion of progesterone from the corpus luteum. Furthermore, when an antibody against this protein was incorporated into luteal cell in vitro, progesterone secretion from these cells was significantly decreased, thus demonstrating that this protein plays a role in the production/secretion of progesterone by the luteal cell. It is the objective of this proposal to determine the specific way in which the K-ras p21 protein affects luteal progesterone secretion and to determine whether this p21 protein plays a role in the secretion of other hormones from the luteum. The K-ras p21 protein is present in all mammalian cells. Thus, the results of the proposed studies will have a significant impact upon the understanding of ovarian hormone secretory mechanisms as well as our understanding of the ways in which all mammalian cells respond to hormones and growth factors.