U.S.-Hungary Joint Fund Project Development for Research on Receptor Mediated Ion Translocation

美国的主要目标是-匈牙利合作社 朱莉安娜·卡多斯博士的研究项目 布达佩斯中央化学研究所和博士。 德里克·卡什，密苏里州大学，哥伦比亚是使用快速 跨膜离子动力学分析技术 离子通道形成介导的通量 神经递质受体如γ-氨基丁酸 （GABA）。 确定绑定与 反应和GABA受体控制的~（36）CL-离子通量 需要快速混合的技术，因为 GABA对受体的快速脱敏作用 易位过程在几百分钟内完成 毫秒 对于现有的快速反应技术，Kardos博士 计划探索多功能淬火流动机 由卡什博士开发，目前正在建造这台机器 在他的实验室里。 项目开发考察。 现金将集中在扩大他们以前的工作， GABA受体与药物的作用 富含GABA受体的制剂。 该项目的资金是通过美国-匈牙利 联合基金，布达佩斯根据既定 指南

The primary objective of this U.S.-Hungary cooperative research project between Dr. Julianna Kardos of the Central Research Institute for Chemistry, Budapest and Dr. Derek Cash, University of Missouri, Columia is to use fast kinetic technique for the analysis of transmembrane ion fluxes mediated by the ion-channel forming neurotransmitter receptor such as gamma-aminobutyric acid (GABA). Determining the relationship between the binding reaction and the GABA receptor-controlled 36CL -ion fluxes requires the techniqus of rapid mixing because - due to rapid desensitization of receptor on exposure to GABA - the translocation process is complete within a few hundred milliseconds. For the existing fast reacting techniques, Dr. Kardos plans to explore the versatile quenched flow machine developed by Dr. Cash and is now constructing the machine in his laboratory. The project development visit by Prof. Cash would focus on extending their previous work on the GABA receptor to drugs which effect its function using a preparation enriched in GABA receptors. Funds for this project are awarded through the US-Hungary Joint Fund, Budapest in accordance with established guidelines.