Radiochemistry Facility for Biomolecule Characterisation in Living Systems

该项目将提供一个微流控放射化学设施，填补新南威尔士州核心成像研究实验室网络的关键能力缺口。它将使用短寿命放射性同位素标记新的生物分子成为可能，以便在活体中表征它们的特征。这一平台将使各种研究成为可能，包括与特定蛋白质靶点结合的新化学探针和纳米颗粒的开发和体内表征、下一代放射化学技术的开发、研究预测学习中大脑可塑性的机制、开发多模式图像分析的新方法，以及了解参与细胞网络失调的分子路径。

This project will provide a microfluidic radiochemistry facility that fills a critical capability gap in the network of core imaging research laboratories in New South Wales. It will enable the labelling of novel biomolecules with short-lived radioisotopes for their characterisation in living subjects. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets, development of next generation radiochemistry technologies, investigating mechanisms of brain plasticity in predictive learning, developing novel methods for multi-modal image analysis, and understanding the molecular pathways involved in dysregulated cellular networks.