Allylic Cation Cycloadditions

本研究的重点将放在烯丙基阳离子与双烯的分子内3+2和4+3环加成反应上。烷氧基烯丙基醇、环丙烷半缩醛和烯丙基亚硫醚将被用作烯丙基阳离子的前体。将在合成稠合的6，7和6，5双环体系的背景下详细研究区域选择性和相对立体化学。%有了这个续约奖，合成有机计划正在支持密苏里大学哥伦比亚分校化学系的Michael Harmata教授的研究。哈马塔博士将专注于开发一类被称为环加成反应的反应，目的是构建含有5，6和7元环的化合物，这些结构经常出现在重要的天然产品中。

The focus of this research will be on intramolecular 3+2 and 4+3 cycloaddition recations of allyl cations with dienes. Alkoxyallylic alcohols, cyclopropane hemiacetals and allylic sulfoxides will be used as progenitors of allylic cations. A detailed study of regioselectivity and relative stereochemistry will be made in the context of the synthesis of fused 6,7 and 6,5 bicyclic ring systems. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Professor Michael Harmata of the Department of Chem,istry at the University of Missouri, Columbia. Dr. Harmata will focus his work on developing a class of reactions known as cycloadditions for the purpose of constructing compounds containing 5,6 and 7-membered rings, structures often occuring in important natural products.