Studies in Asymmetric Synthesis

这一奖项是卡雷拉博士化学博士后奖学金的首次授予。将进行结构明确的稀土配合物的设计和合成，用于不对称催化杂Diels-Alder环加成反应。要研究的体系包括非手性醛与功能化双烯的反应。双烯体上的保护基团将提供与络合物的第二接触点，以提高形成一个非对映异构体过渡态的选择性。这些立体效应将导致产品选择性的提高。%Diels Alder反应在可由其制备的不同类型的分子中具有非常广泛的用途。这项建议将研究使反应更具选择性的方法。这一结果将导致合成新的分子，其中一些可能具有重要的生理特性。

This award is the starter grant increment of Dr. Carreira's Postdoctoral Fellowship in Chemistry. The design and synthesis of structurally well-defined rare earth complexes for the asymmetric catalysis of the hetero-Diels-Alder cycloaddition reaction will be carried out. Systems to be studied include the reactions of achiral aldehydes with funcionalized dienes. Protecting groups on the dienophile will provide a second contact point with the complex to enhance the selectivity of the formation of one diastereomeric transition state. These steric effects will lead to increased product selectivity. %%% The Diels Alder reaction is very versatile in the different kinds of molecules that can be prepared by it. This proposal will study means by which the reaction can be made more selective. The results will lead to the synthesis of new molecules some of which could have important physiological properties.