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Investigating the role of histone variants in circadian timekeeping in mice

Investigating the role of histone variants in circadian timekeeping in mice
研究组蛋白变异在小鼠昼夜节律中的作用
批准号：
461757
负责人：
Cheng Hai-Ying M
金额：
$66.6万
依托单位：
University of Toronto Mississauga (ON)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-03-01 至 2027-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=461757&lang=en
关键词：
Animal Behaviour Circadian Rhythms Confocal Microscopy Epigenetic Regulation Histone Variants Next-Generation Sequencing Suprachiasmatic Nucleus Transcriptomics Transgenic And Knockout Mouse Models Viral Gene Delivery Methods

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中文摘要
翻译
我们生活在一个24小时的世界里，我们的日常活动是围绕着昼夜循环进行的。我们中的许多人每天几乎在同一时间起床、吃饭、上班和睡觉。我们的内部器官也以类似的方式运作，改变我们的身体。
英文摘要
We live in a 24-hour world where our daily activities are organized around the day-night cycle. Many of us wake up, eat our meals, go to work, and sleep at approximately the same time every day. Our internal organs behave in a similar fashion, changing th
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Investigating the role of histone variants in circadian timekeeping in mice
Investigating the functions of the pluripotency factor SOX2 within the mammalian suprachiasmatic nucleus (SCN): implications for circadian timekeeping, SCN clock development, and mood disorders
Clocks for a healthy brain: dissecting the role of the pluripotency factor SOX2 in biological timekeeping
Translational and post-translational control of the mammalian circadian clock
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