NSF Young Investigator

这是国家科学基金会青年研究人员奖。Henson博士实验室的目标是研究无脊椎动物血细胞(体腔细胞)中细胞形状变化和基于微丝和微管的运动的分子机制。细胞骨架相关蛋白将通过光镜和电子显微镜免疫细胞化学方法在细胞中分离、鉴定和定位。钙对形状变化的调节也将被讨论。这是国家科学基金会青年研究人员奖。汉森博士对细胞如何改变形状这个基本而重要的问题很感兴趣。细胞形状的变化对细胞功能(包括运动)和生物体发育至关重要。汉森博士目前正在使用海胆体腔细胞作为模型，研究与细胞运动相关的形状变化。这些细胞类似于高等动物的白细胞，它们改变形状的能力对于海胆抵御微生物病原体的能力至关重要。

This is a National Science Foundation Young Investigator Award. The goal of Dr. Henson's laboratory is to investigate the molecular mechanism of cell shape changes and microfilament and microtubule based motility in an invertebrate blood cell (the coelomocyte). Cytoskeletal associated proteins will be isolated, characterized, and localized in the cells using light and electron microscopic immunocytochemical methods. The regulation of shape changes by calcium will also be addressed. %%% This is a National Science Foundation Young Investigator Award. Dr. Henson is interested in the fundamental and important question of how cells change their shapes. Cellular shape changes are critical to cellular functions (including movement) and organismal development. Dr. Henson is currently using sea urchin coelomocytes as models for studying shape changes associated with cellular motility. These cells are analogous to white blood cells of higher animals, and their ability to change shape is critical to the ability of sea urchins to defend themselves against microbial pathogens.