Intercellular Communication of Bovine Luteal Cells: Role of Cyclic AMP

这是排行榜职业进步奖。本研究旨在探讨环磷酸腺苷(CAMP)在黄体生长、分化和退化过程中对细胞内通讯的调控作用。近期的目标是研究(1)黄体细胞之间接触性细胞间通讯的个体发育，以及(2)在黄体生长、分化和退化过程中，cAMP调节剂(如黄体生成素、Forsklin)对细胞内cAMP浓度和黄体细胞接触性细胞间通讯的影响。%这是职业发展奖，是国家科学基金会妇女研究机会活动之一。获奖者的主要研究兴趣是家畜黄体功能的调节，重点是黄体细胞在黄体生长、发育和退化过程中的相互作用。这是生殖生理学中的一个重要问题。该奖项将有助于促进获奖者的科学事业以及家畜生殖生物学的基本知识。

This is a ROW Career Advancement Award. The goal of this research is to study the role of cyclic AMP (CAMP) in regulating intracellular communication during growth, differentiation and regression of corpora lutea. The immediate objectives are to study (1) ontogeny of contact-dependent intercellular communication among luteal cell types, and (2) effects of regulators of CAMP (e.g. luteinizing hormone, forskolin) on intracellular concentrations of CAMP and contact-dependent intercellular communication in selected luteal cells during luteal growth, differentiation and regression. %%% This is a Career Advancement Award which is one of the Research Opportunities for Women activities of the National Science Foundation. The main research interest of the awardee is the regulation of the function the corpus luteum of domestic animals, with emphasis on interactions among luteal cells during luteal growth, development, and regression. This is an important problem in reproductive physiology. This award will contribute to the advancement of the awardee's scientific career as well as to basic knowledge of the reproductive biology of domestic animals.