Factors that Effect Signal Transduction by Nuclear Receptors

9307388山本糖皮质激素受体是一种细胞内因子，与特定类型的循环激素类固醇结合；这种激素与受体的相互作用触发了受体与DNA上特定压力的结合，并随后改变了附近基因的表达。最近的证据表明，除了激素外，某些其他因素也与受体相互作用并改变其活性；其中包括热休克蛋白、磷酸依赖体和DNA本身。Yamamoto博士提出，这些其他相互作用的物种也可能向受体传递信号信息，受体因此可以整合来自不同调节输入途径的信号。他将研究这些不同的受体-配体相互作用的性质和后果，使用一系列分子，遗传，生化和结构方法。由于信号转导过程是细胞内和细胞间交流的普遍和基础，因此更好地理解糖皮质激素受体信号传导途径，以及多种信号输入可能收敛于单一因素的机制，对于分析许多生物信息交易通常具有重要意义。＊＊＊

9307388 Yamamoto The glucocorticoid receptor is an intracellular factor that binds to a specific class of circulating hormonal steroids; this hormone-receptor interaction triggers binding of the receptor to specific stress on DNA and a subsequent change in the expression of nearby genes. Recent evidence suggests that in addition to the hormone, certain other factors also interact with the receptor and modify its activity; these include a heat shock protein, phosphate addicts, and DNA itself. Dr. Yamamoto proposes that these other interacting species may also convey signaling information to the receptor, and that the receptor consequently serves to integrate signals from different regulatory input pathways. He will investigate the nature and consequences of these various receptor-ligand interactions, using a range of molecular, genetic, biochemical and structural approaches. As signal transduction processes are universal and fundamental for communication within and between cells, a better understanding of the glucocorticoid receptor signaling pathway, and of the mechanisms by which multiple signaling inputs may converge on a single factor, could be generally significant for analyses of many transactions of biological information. ***