Molecular Quantitative Genetics of Inbreeding Depression and Hybrid Breakdown in Arabidopsis

分子生物学的定量遗传学方法可用于研究育种抑制和杂交击破。近交抑郁症的遗传基础是一个悬而未决的问题，对农业和遗传学的许多问题都有影响。例如，杂种优势（避免近交衰退）是植物育种家获得的作物产量增加的很大一部分原因。远亲种群之间的杂交可能产生适应性降低的后代（杂交破坏）。表型可塑性和基因型环境相互作用在农业和野生物种中也很重要。尽管经过多年的研究，这些现象的遗传基础仍不清楚。利用最新发展的分子生物学技术，阐明近交抑郁和近交抑郁的遗传基础是可行的。这项技术将用于问1)是什么导致杂交活力？2)基因型环境互作对杂种活力有贡献吗？3)基因表达的变化是如何引起基因型环境相互作用的？4)是什么原因导致混合型故障？这项研究将对了解农业种群和自然种群的遗传学具有重要意义。

9307747 Mitchell Olds Molecular Biological approaches to quantitative genetics can be used to study in breeding depression and hybrid breakdown. The genetic basis of inbreeding dpression is an unanswered question with implications for many problems in agriculture and genetics. For example, hybrid vigor (avoidance of inbreeding depression) is responsible for a large portion of the increases in crop yield obtained by plant breeders. Crosses between distantly related populations may produce offspring with reduces fitness (hybrid breakdown). Phenotypic plasticity and genotype environment interaction may also be important in agricultural and wild species. Despite many years of inquiry, the genetic basis of these phenomena remains unclear. %%% Using recently developed techniquesin molecular biology it is now feasible to elucidate the genetic basis of ombreeding depression and outbreeding depression. This technology will be used to ask 1) What causes hybrid vigor? 2) Does genotype environment interaction contribute to hybrid vigor? 3) How do changes in gene expression cause genotype environment interaction? 4) What causes hybrid breakdown? This research will have important implications for understanding the genetics of agricultural and natural populations.