Research Initiation Award: Block Copolymer Adsorption to Self-Assembled Lipid Monolayers

卡耐基梅隆大学（Carnegie Mellon University）蒂尔顿 摘要 本研究的目的是确定嵌段共聚物在自组装脂质表面的气-水界面吸附的机理。 扫描角反射法将用于测量嵌段共聚物吸附时的时间分辨层厚度和折射率。 在朗缪尔槽中的另外的实验集中于确定共聚物对-A等温线的影响。 动力学和平衡的结果，从这些和其他测量将被用来帮助了解嵌段共聚物分子和脂质聚集体之间的相互作用。 嵌段共聚物两亲物的存在可以改进支持各种消费品的许多现有和新兴技术。 它们有助于抑制红细胞溶解，减少培养物中真核细胞的破裂，并稳定乳剂。

CTS-9308569 Carnegie Mellon University Robert D. Tilton ABSTRACT The objective of this research is to determine the mechanism of adsorption of block copolymers to the surface of self-assembled lipids at the vapor-water interface. Scanning angle reflectometry will be used to measure time-resolved layer thicknesses and refractive indexes as the block copolymers adsorb. Additional experiments in a Langmuir trough focus on determining the effect of the copolymer on -A isotherms. Kinetic and equilibrium results from these and other measurements will be used to help understand the interaction between the block copolymer molecules and the lipid aggregate. The presence of block copolymer amphiphiles can improve many existing and emerging technologies which support a variety of consumer products. They help to inhibit lysis of red blood cells, to reduce rupture of eucaryotic cells in cultures, and to stabilize emulsions.