Development of a Biophysical Source Model to Evaluate Sensitivity of Unipolar and MAP Bioelectrode Recordings in Cardiac Tissue

9309181亨利克斯研究启动基金的目标是开发一种心脏组织的数学模型，用于评估表面各种类型的心电记录对电激活潜在传播的变化的敏感性。将对单极和单相动作电位图进行建模，并将使用心脏组织的二维和三维双域模型。这项研究将包括包括重返大气层在内的复杂激活前沿。这项研究很重要，因为它可以提高细胞外测量在各种电生理程序中的效用。***

9309181 Henriquez The objectives of the research initiation grant is to develop a mathematical model of cardiac tissue for evaluating the sensitivity of various types of electrogram recordings at the surface to changes in the underlying spread of electrical activation. Both unipolar and monophasic action potential electrograms will be modeled and two and three dimensional bidomain models of cardiac tissue will be used. This study will include complex activation fronts including reentry. This research is important since it could lead to the improvement of the utility of extracellular measurements for a variety of electrophysiological procedures. ***