Chimeric molecules for precision protein modification

该项目旨在解决关于蛋白质的自然修饰如何引起细胞内功能变化的基本问题。该项目希望通过开发一个合成平台，发现一类可以触发蛋白质精确修饰的新型嵌合分子，从而在有机化学和化学生物学领域产生新的知识。预期的结果包括对特定修饰如何调节蛋白质和细胞功能的详细了解。这个跨学科项目的重大好处包括获得用于基础研究的新一类分子，这些分子也可能在澳大利亚不断发展的生物技术部门中用于细胞工程应用。

This project aims to address fundamental questions on how natural modifications of proteins cause functional changes inside cells. The project expects to generate new knowledge in the areas of organic chemistry and chemical biology through the development of a synthetic platform for the discovery of a novel class of chimeric molecules that can trigger precise modifications of proteins. Expected outcomes include a detailed understanding of how specific modifications modulate protein and cellular function. Significant benefits of this interdisciplinary project include access to a new class of molecules for basic research that may also find use for cell engineering applications within the growing biotechnology sector in Australia.