Development of the Visual Projection in the Embryo

这个项目将研究大脑发育过程中某些特定分子的生物学意义。这个项目将测试一个假设，即神经细胞过程的生长尖端，或生长锥，使用细胞外基质分子和特定细胞粘附分子的受体，在大脑中导航到合适的目标。这些分子的作用将在发育中的视觉系统中使用功能阻断试剂进行表征。此外，生物化学、免疫学和分子技术的结合将用于检查这些分子在发育过程中的空间和时间分布。这些研究结果将为生长锥诱导和途径选择的细胞和分子基础提供重要的新信息。长期目标是更好地理解发育过程中调节特定神经连接形成的细胞和分子机制。*** 9311198 Sakaguchi本项目将研究| ~发育过程中某些特定分子的生物学意义W | ~!!!F ~ ~ (Times New Roman Symbol & Arial " h ？？ aka William Proctor, IBN William Proctor

9311198 Sakaguchi This project will investigate the biological significance of certain specific molecules during the development of the brain . This project will test the hypothesis that the growing tips of nerve cell processes, or growth cones, use receptors for extracellular matrix molecules and specific cell adhesion molecules to navigate through the brain to their appropriate targets. The role of these molecules will be characterized using function-blocking reagents in the developing visual system. In addition, a combination of biochemical , immunological and molecular techniques will be used to examine the spatial and temporal distribution of these molecules during development. The results of these studies will provide important new information on the cellular and molecular basis of growth cone guidance and pathway selection. The longer term goal is to better understand the cellular and molecular mechanisms that regulate the formation of specific nerve connections during development. *** 9311198 Sakaguchi This project will investigate the biological significance of certain specific molecules during the develop | ~ w | ~ ! !. !. F ~ ~ ( Times New Roman Symbol & Arial " h ? ? saka William Proctor, IBN William Proctor, IBN