Neural Computation: Modeling the Neural Basis of Blood Pressure Control

小行星9311388 这是一项研究孤束核（NTS）神经元在压力感受器输入的转化和整合中的作用的建议，作为控制血压的系统的一部分。 该项目非常重要，因为它为了解血压控制的神经基础迈出了第一步。 这项工作的动机是惊人的观察，单一的压力感受性NTS神经元不再现其压力感受器输入模式，并出现了非线性的反应，动脉压的变化。 这些结果表明，NTS神经元的反应是由主动膜反应压力感受器输入。 工作计划遵循一个合乎逻辑的进展：在体内记录NTS神经元的突触输入和突触后反应，然后构建NTS神经元的神经元和网络模型，以测试实验数据是否可以解释神经元的反应。 这些计算模型将在并行计算平台上实现。

9311388 Schwaber This is a proposal to study the role of nucleus tractus solitarii (NTS) neurons in the transformation and integration of baroreceptor input as part of the system that controls blood pressure. The project is very important because it provides a first step towards understanding the neural basis of blood pressure control. The work is motivated by the striking observation that single baroreceptive NTS neurons do not reproduce their baroreceptor input pattern, and appear to have nonlinear responses to changes in arterial pressure. These findings suggest that NTS neuron responses are produced by active membrane responses to baroreceptor inputs. The plan of work follows a logical progression: in vivo recording of synaptic inputs and postsynaptic responses of NTS neurons, followed by construction of neuronal and network models of NTS neurons to test whether the experimental data can account for the neurons' responses. These computational models will be implemented on a parallel computing platform.***